In EC, CSCs isolated from the ESCC cell line EC9706 were resistant to DNA damage through impaired induction of p53 and declined G1 checkpoint arrest, and presented a slow-cycling status with a lower level of phosphorylated Stat3, c-Myc, and a higher level of p27 when compared with the non-CSCs [156]. This evidence concerns the gene TP53 and esophageal squamous cell carcinoma.