Studies have proved that stromal constituents of the TME can activate EMT through secreting various chemokines, cytokines, and activating several signaling pathways such as TGFβ, WNTs, NOTCH, and Hedgehog to maintain cancer stemness and promote tumor progression and metastasis in several types of cancers [176], including EC [177]. This evidence concerns the gene TGFB1 and neoplasm.