Strikingly, distributions of six major cancer types (invasive breast cancer, non-small cell lung cancer, colorectal adenocarcinoma, glioblastoma, endometrial carcinoma, and ovarian epithelial tumor) of the patients with somatic mutations of the PRNP gene were shown to be significantly different from distributions of the six major cancer types of total patients (Figure 2). The gene discussed is PRNP; the disease is ovarian epithelial tumor.