In detail, genetic CJD has been reported to carry G114V, D178N-129V, V180I, T183A, T188K, E196K, E196A, E200K, E200G, V203I, R208H, V210I, E211Q, I215V, M232R, and P238S mutations; double octapeptide deletions; and octapeptide insertions in the PRNP gene. This evidence concerns the gene PRNP and Creutzfeldt Jacob disease.