CDK8 and infection: Huh7 cells were treated with dimethyl sulfoxide (DMSO) or Senexin A solubilized in DMSO at the start of synchronized infections, and virus replication was assessed at 24 hpi (after one round of virus replication) (Figure 3C) and at 36 hpi (coincident with significantly increased CDK8 expression, Figure 1C and Figure 3D).