Logically, differentiation is accompanied by the downregulation of the transcription factor POU5F1/OCT3/4 (reflecting the immunoexpression pattern of these neoplasms), which has also been linked to increased resistance to cisplatin [157], namely by downregulating the aforementioned NOXA and PUMA but, also, the miR-17/-106b cluster, potentiating the activation of p21 [51,101,158]. This evidence concerns the gene POU5F1 and neoplasm.