It is known that MSCs are key participants of the tumor microenvironment and, in addition to being able to suppress various tumor growth, they can promote tumor growth and metastasis, as well as stimulate neovascularization by expressing multiple pro-angiogenic and trophic factors such as VEGF, IL8, TGF-β, EGF, and PDGF [17]. This evidence concerns the gene EGF and neoplasm.