The model systems included common human AML cell lines (HL60, OCI-AML2, KG1a, U937), AML cell lines with leukaemic stem cell (LSC) features (TEX, M9-ENL1, AML 8227), murine bone marrow stem/progenitor cells transduced with oncogenes of interest (AML1-ETO, MN1, MLL-AF9, HOX9A-Meis1) or a leukaemic niche-like system. The gene discussed is RUNX1; the disease is acute myeloid leukemia.