Roberts and colleagues recently reported that in individuals with CDH1 pathogenic variants identified by the MultiGene Panel Testing (MGPT), who did not meet the established clinical testing criteria, the cumulative incidence of GC at age 80 years was significantly lower: 42% (95% CI, 30–56%) for men and 33% (95% CI, 21–43%) for women [9]. The gene discussed is CDH1; the disease is gastric cancer.