Specifically, in everolimus-resistant HCC cell lines, the treatment with vitamin D induced EMT by increasing the expression of the epithelial markers E-cadherin and cytokeratin 18 and by reducing expression of the mesenchymal marker vimentin, compared to untreated everolimus-resistant HCC cell lines, demonstrating the capability of vitamin D to directly act in the modulation of everolimus resistance by reverting the mesenchymal-like phenotype to an epithelial-like phenotype [25]. This evidence concerns the gene CDH1 and hepatocellular carcinoma.