CCND1 and neoplasm: In particular, while low levels of vitamin D diet (25 IU: 0.625 μg) allowed an increase in tumor growth, the continuous systemic perfusion of the 25(OH)D (2000 pmol/24 h) or 1,25(OH)2D (12 pmol/24) inhibited tumor growth and lung metastasis development by downregulating cell cycle progression markers expression, such as cyclin D1, without increased blood calcemia [130].