NAA10 and microphthalmia: For example, in patients suffering syndromic microphthalmia, various mutations in the proximal canonical PAS of the N-alpha-acetyltransferase 10, NatA catalytic subunit (NAA10) gene result in isoform lengthening from increased use of a distal rare AAATAA PAS, leading to decreases in mRNA expression of approximately 50% [175].