As described above, APA of SLC6A4 plays a role in several neurological conditions and interestingly treatment of mice with the SLC6A4-selective antidepressant/anxiolytic drug fluoxetine, which has been shown to reduce anxiety disorders, increases expression of the distal polyadenylation form of SLC6A4 [216,413]. Here, SLC6A4 is linked to anxiety disorder.