For instance, it has been shown that TERT directly interacts with β-catenin and, as a consequence, stimulates epithelial-mesenchymal transition (EMT) and stemness of cancer cells, and, by interaction with NF-κB p65, up-regulates the expression of metalloproteinases (MMPs) in cancer cells [23,24]. This evidence concerns the gene NFKB1 and cancer.