Expression of HLA-A, HLA-B, HLA-C, and HLA-E were included in this study in order to broaden the knowledge on how IFN-γ and 5-aza-dC affect both classical and non-classical HLA molecules giving that a concomitant deregulation of HLA class Ia and Ib molecules is associated with immune evasion in cancer [37]. This evidence concerns the gene HLA-B and cancer.