Furthermore, previous studies show that HLA-G expression can be induced in different tumor cell lines and mesenchymal stem cells by treatment with the demethylating agent 5-aza-2′-deoxycytidine (5-aza-dC) indicating that HLA-G expression is regulated partly by methylation-mediated repression [33,34,35]. The gene discussed is HLA-G; the disease is neoplasm.