IBS-related visceral pain treatment is approached though dietary measures (fiber supplementation, low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols diet) and pharmacological resources, such as antispasmodics, antidepressants (TCA and SSRI), 5-HT3 antagonists (alosetron), nonabsorbed antibiotic (rifaximin), secretagogues (lubiprostone, linaclotide), μ and κ agonist, δ antagonist, H1 antagonist (ebastine), GABAergic agents (gabapentin and pregabalin), and peppermint oil [24]. The gene discussed is HTR3A; the disease is irritable bowel syndrome.