Mutations in many different genes have been associated with fALS, starting from the superoxide dismutase 1 (SOD1) gene (coding for an antioxidant enzyme), to the more recently described mutations in TAR DNA-binding protein 43 (TDP-43), ALS-linked fused in sarcoma/translocated in liposarcoma (FUS/TLS), and other genes (see, for review [2]). The gene discussed is TARDBP; the disease is sarcoma.