TP53 and neoplasm: The importance to restrict FBXW7 function during squamous carcinogenesis is also highlighted by the fact that p53, a positive regulator of FBXW7 expression [73], is commonly mutated in SCCs, suggesting that disruption of FBXW7 function can also be sustained by alterations in signaling pathways, such as mutation of p53, which allows tumor cells to gain hallmark properties.