CD4 and Kaposi's sarcoma: Since our transcriptomic analysis of EpKS lesions revealed no evidence for HIV-1 transcripts directly in KS lesions (Lidenge et al. in submission), the lack of outcome association with both the CD4+ T-cell count and HIV-1 viremia could be due to an indirect impact of HIV on immune function as opposed to simply CD4+ T-cell depletion.