The results confirmed an existing association between IL-10 gene polymorphisms and polymorphism of tumor TNFα, interleukin 1α-β-RN (IL-1α-β-RN), collagen type-l alpha (COLIA1) and vitamin D receptor (VDRs) genes in PD, which may arise under a common dysbiotic scenario following a local and systemic response. The gene discussed is TNF; the disease is Parkinson disease.