Therapy-treated tumor cells succumbing to ICD release certain damage-associated molecular patterns (DAMPs), such as early lysosomal adenosine triphosphate (ATP) secretion (find-me signal), pre-apoptotic translocation of the endoplasmic reticulum (ER) chaperone protein calreticulin (ecto-CALR) to the tumor cell surface (eat-me signal) and post-mortem release of the nuclear protein high mobility group box 1 (HMGB1) [16,25,26]. The gene discussed is CALR; the disease is neoplasm.