PRMT5 and infection: We also performed experimental infection of five cattle carrying the susceptible alleles BoLA-DRB3*1601/*1601, which are associated with an increased risk of developing BLV infection with HPVL, and we confirmed that PRMT5 is upregulated in response to BLV infection (Figure 2A) and its level of upregulation was strongly correlated with BLV PVL (Figure 2B).