Our findings in this study corroborated the tumor-suppressive roles of miR-142-3p, in that transfection of CRC cells with miR-142-3p mimic molecules resulted in decreased expressions of LGR5, β-catenin, mTOR, and IL-6 as well as reduced SPs, as a surrogate of reduced ABCG2 expression. Here, LGR5 is linked to colorectal carcinoma.