LRRK2 and REM sleep behavior disorder: LRRK2 mutations also show sex- specific phenotypic effects, including milder motor symptoms and higher cognitive function, a lower incidence of REM sleep behavior disorder (RBD) and worse thermoregulation scores in men with LRRK2-G2019S mutation compared to men with iPD, whereas women with LRRK2-G2019S had worse motor complications than women with iPD [13].