To elucidate signaling pathways involved in the responses to MI and CSE gene deletion, separately and in combination, we documented expression of selected genes associated with cardiac hypertrophy (ventricular Nppa, Nppa, Myh7, and Myh6), cardiac remodeling and fibrosis (atrial MiR21a, ventricular Tgfb1, Gata4, Col1a1, Nrf2, Agtr1, and Ace), and antioxidant and apoptosis pathways genes (Casp3 and Akt1). Here, NPPA is linked to cardiac hypertrophy.