PTK2B and myocardial infarction: Moreover, Miao et al. [22] found greater early (up to 8 days) post-MI pathological remodeling and dysfunction post-MI in CSE−/− mice, which was ameliorated by NaHS administration acting via promotion of M2 macrophage polarization, achieved by accelerating internalization of integrin β1 and activating the downstream Src-FAK/Pyk2-Rac pathway [28].