PARP1 and Huntington disease: Indeed, a recent study found that the weak PARP inhibitor 3-aminobenzamide either alone or especially in combination with the NMDA receptor antagonist, memantine, improved bioenergetics (striatal NAD and ATP content) and mitochondrial markers (striatal succinate dehydrogenase activity) in the 3-nitropropionic acid-induced model of HD [211].