PRF1 and melanoma: In addition, depsipeptide, a potent histone deacetylase 1/2 inhibitor, enhances effector T cell function by up-regulating Perforin expression in melanoma-specific, antigen-stimulated effector T cells as well as FAS expression on B16-F10 melanoma to induce tumor cell apoptosis in vitro and in vivo [143].