In particular, in patients with inflammatory vasculitides, the major ANCA antigen targets are the proteinase-3, cytoplasmic granular with accentuation between nuclear lobes (cANCA), while in those with IBD, the target is the myeloperoxidase, which is a fine, homogenous, diffuse rim-like staining of perinuclear cytoplasm (pANCA) [56]. This evidence concerns the gene MPO and irritable bowel syndrome.