In mouse models, Doo et al. demonstrated that EOC tumors treated with the PORCN inhibitor WNT974 had increased CD8+ T cells and enhanced functioning of infiltrating CD4+ and CD8+ T cells, indicating that inhibition of Wnt signaling with WNT974 has immunomodulatory effects in the tumor microenvironment of EOC [29]. Here, CD8A is linked to neoplasm.