A total of 21 out of 87 patients (24.1%) were positive for the HLA-DRB1*15 allele, which is significantly higher than the expected 11.4% allele frequency in HC (p < 0.001), confirming the well-established role of this allele in MS pathogenesis [33]. This evidence concerns the gene HLA-DRB1 and myeloid sarcoma.