Recent studies have further established the role of HLA-DRB1*15:01 in early-onset (pediatric and adolescent) MS (EOMS), which accounts for 3–5% of all MS cases, while the role of HLA-DRB1*04 and HLA-DRB1*03 remains to be clarified [9,10,11]. Here, HLA-DRB1 is linked to myeloid sarcoma.