The present study attempts to expand the existing data on HLA and MS by investigating the influence of HLA-DPB1* alleles on disease risk and resistance in a Hellenic sample of 100 patients of both EOMS and AOMS, using healthy controls (HC) for comparisons, given the pre-existing difference in HLA-DRB1 allele frequencies in EOMS and AOMS in our ethnic group [11] and the total absence of information on HLA-DPB1 genotyping in the Hellenic MS population. The gene discussed is HLA-DPB1; the disease is myeloid sarcoma.