AGT and endothelial dysfunction: For instance, overexpression of an adipokine, CTRP6 in spontaneously hypertensive rats (SHRs) decreased Ang II expression, alleviated Ang II-induced hypertension and endothelial dysfunction, and increased p-PPARγ and p-ERK1/2 protein levels in the brain, suggesting that the protective effects of CTRP6 are mediated through ERK signaling and PPARγ activation [39].