Among T5KO-HB associated genes that are over-expressed in human HCC and correlated with poor patient survival, ATIC, RUVBL1, ANXA2, BZW2 and TAGLN2 are involved in cell-cell adhesion, and RUVBL1, CCNB1 and DYNLT1 are involved in cell division. This evidence concerns the gene RUVBL1 and hepatocellular carcinoma.