In pursuing the mechanism by which BRD2, a bromodomain (BET) protein, predisposed to epilepsy [4, 5], we found that HETs, which are overtly normal [1, 3], not only have significantly longer lifespans but also show healthier-aging phenotypes, including reduced cancer incidence and improved kidney function, as compared to wildtype mice. This evidence concerns the gene BRD2 and cancer.