In rats with stroke‐reperfusion at 1 and 24 hr, the beneficial effect of BPC 157 therapy during reperfusion was associated with strongly elevated (Egr‐1, Akt‐1, Kras, Src, Foxo, Srf, Vegfr2, Nos1, and Nos3) and decreased (Nos2 and Nfkb1) gene expression, while Mapk1 remained unchanged throughout both time intervals (Figure 6). The gene discussed is NOS3; the disease is stroke disorder.