BRCA1 and breast cancer: Correlation analysis of the first 10 significant differential genes in the GSE61304 expression profile and the known genes of breast cancer was conducted and the gene interaction network map was constructed (Figure 1B), finding that among the top 10 differential genes, NEK2 gene was at the core of the network map and had an interaction with genes known to be related to breast cancer such as AKT1 and BRCA1.