In addition, using publicly available gene expression datasets, we found ACE2 expression upregulated by estrogen and androgen, downregulated in type II diabetes (T2D) and by inflammatory cytokines in various human and mouse tissues, and a significant negative correlation of ACE2 expression with viral infection, in particular herpes simplex virus 1 infection response genes in many tissues across different individuals. Here, ACE2 is linked to type 2 diabetes mellitus.