As shown in Figures 3 and 4 and Figure S4, HOXD3 was higher expressed in HCC tissues than the counterparts' tissues, and disease‐free interval, progression‐free interval, disease‐specific survival and overall survival were attributed to the high expression of HOXD3, suggesting that HOXD3 plays the role of prognostic biomarkers in HCC. The gene discussed is HOXD3; the disease is hepatocellular carcinoma.