Furthermore, ITGA2 affected the biological processes of HCC cells with ERK1/2 involved cell signalling pathway, which was consistent with the research of ITGA in salivary adenoid cystic carcinoma (SACC),40 breast cancer,41, 42 pancreatic cancer43 and gastric canceryy.44 This evidence concerns the gene MAPK3 and hepatocellular carcinoma.