Most studies report a decrease in anxiety‐like behavior, or a disinhibition of caution in APP mice as early as 2 months of age (Cheng et al., 2007; Cissé et al., 2011; Dubal et al., 2015; Harris et al., 2010; Murakami et al., 2011; Sanchez et al., 2012) or no anxiety‐related phenotype (Dekens et al., 2018; Fujikawa et al., 2017; Wright et al., 2013). The gene discussed is APP; the disease is Anxiety.