Sjögren‐Larsson syndrome (SLS; OMIM #270200) is a neurometabolic disorder caused by fatty aldehyde dehydrogenase (FALDH) deficiency1 due to biallelic mutations in ALDH3A2. 2Patients suffer from intellectual disability, spastic diplegia, ichthyosis, and retinopathy.3, 4. The gene discussed is ALDH3A2; the disease is Sjogren-Larsson syndrome.