Sjögren‐Larsson syndrome (SLS; OMIM #270200) is a neurometabolic disorder caused by fatty aldehyde dehydrogenase (FALDH) deficiency1 due to biallelic mutations in ALDH3A2. 2Patients suffer from intellectual disability, spastic diplegia, ichthyosis, and retinopathy.3, 4. This evidence concerns the gene ALDH3A2 and Intellectual disability.