ALDH3A2 and spastic diplegia: Sjögren‐Larsson syndrome (SLS; OMIM #270200) is a neurometabolic disorder caused by fatty aldehyde dehydrogenase (FALDH) deficiency1 due to biallelic mutations in ALDH3A2. 2Patients suffer from intellectual disability, spastic diplegia, ichthyosis, and retinopathy.3, 4