PCOS patients, compared to the women without hyperandrogenism, had significantly higher concentrations of TT (P < 0.0001), A (P = 0.0006), and 17OHP (P = 0.0002) and worse metabolic profile characterized by higher fasting insulin (P = 0.206), HOMA-IR (P = 0.0355), TG (P = 0.0135), and lower HDL (P = 0.0105) levels. This evidence concerns the gene INS and polycystic ovary syndrome.