In contrast, ALP activity and protein amount, which increase with periodontitis, were significantly higher in the healthy H-Hb group (117.31 ± 150.18 μU/pocket and 19.84 ± 12.38 μg/pocket, respectively) than in the healthy L-Hb group (63.60 ± 118.98 μU/pocket and 11.74 ± 8.53 μg/pocket, respectively) (P < 0.01). Here, GSTM1 is linked to periodontitis.