INS and type 2 diabetes mellitus: However, the interface between GCKR variants in the GCKR locus, altered glucose metabolism and metabolite levels in the non-gravid state is somewhat paradoxical in that the C allele of rs1260326 is associated with a greater risk of type 2 diabetes, higher levels of fasting glucose and insulin as well as insulin resistance, but lower levels of fasting triacylglycerols, alanine, leucine and isoleucine [42–44].