S100A8, S100A9, and S100A12 encode proteins that are well-known markers of acute inflammation and previously implicated in several other inflammatory and autoimmune diseases including systemic lupus erythematosus, rheumatoid arthritis, and atherosclerosis (Austermann et al. 2018; Oesterle and Bowman 2015). This evidence concerns the gene S100A8 and rheumatoid arthritis.