It has been shown in some experimental colitis studies that vitamin D is useful for healthy bowel operation22, and that the loss or overexpression of VDR expression, worsens or alleviates symptoms in experimental colitis models, respectively, and it is seen as a potential cause of increased mucosal permeability, increased intestinal epithelial cell apoptosis, increased mucosal bacterial burden, and increased colitis symptoms in autophagy22,23. The gene discussed is VDR; the disease is colitis.