AKT1 and Alzheimer disease: Other enriched pathways that are previously reported with a key role in AD include Focal adhesion [44], ECM-receptor interaction [45], Ras signaling pathway [46], MAPK signaling pathway [47], Rap1 signaling pathway [48], etc. Many of the top enriched pathways are related to cancer, such as PI3K-Akt signaling pathway, prostate cancer and small lung cancer.