APOE gene and its corresponding protein, a top risk factor of AD, is found in one of the subnetworks involving 1 SNP and 5 genes, including LRP2, PPARG, LPL, LPLRAP1 and GHIHBP1. Across all the subnetwoks, we observed that there are multiple trans-omic paths from SNPs to genes and then proteins. This evidence concerns the gene APOE and Alzheimer disease.