PTPN11 and Alzheimer disease: Top nodes by degree in this subnetwork included proteins PIK3R1, GRB2, FYN, CD44, RPS2, BCL2L1, BCL2L1 and PTPN11, and genes EP300 and SPCS3. Most hub nodes are also found to have the top centrality value in betweenness and closeness, such as PIK3R1, FYN, and EP300. Majority of these genes and proteins have been previously reported in association with AD.