Previous studies have reported that discordance is also associated with a lower likelihood of remission in patients with RA and PsA [36]; greater joint destruction and functional impairment in RA [37], and higher Disease Activity Score (DAS28) and C-Reactive Protein (CRP) after the 24 weeks of disease-modifying therapy in early RA [38]. This evidence concerns the gene CRP and rheumatoid arthritis.