Cross-sectional age-specific curves for the ER/HER2 combinations (Fig. 1b) show incidence of all subtypes increasing rapidly with age, until the approximate age of menopause, age 50 years; thereafter, the increase continued more gradually up to 70 years for ER+/HER2− tumours, but there was no further increase for ER− tumours or ER+/HER2+ tumours. The gene discussed is ERBB2; the disease is neoplasm.