AVP and cardiovascular disorder: To investigate if a genetic predisposition to change ADH regulation contributes mechanistically to the risk of alcohol linked cardiovascular disease, we investigated eQTLs with interactions in cardiovascular tissues (aorta, atrial appendage, left ventricle, tibial artery) and the lung, integrating HaploReg (version 4.1)49,50 data on regulatory motifs and histone marks (Fig. 3).