Human and mouse tumour cells driven by deregulated over-expression of c-MYC are highly dependent on the anti-apoptotic protein MCL-1 for survival and the MCL-1-specific BH3 mimetic drug S63845 induces dose dependent apoptotic death in murine Eμ-Myc as well as human Burkitt’s lymphoma cell lines [9, 10]. The gene discussed is MCL1; the disease is Burkitt lymphoma.