Only a few genes showed opposite expression trends in the two groups: LGALS7) was elevated in KJ but decreased in KC, while 12 genes (CD34, CHST6, COLGALT2, DKK2, KDR, KERA, MAMDC2, MME, NANOS, PDGFD, RECK, STEAP4) were decreased in KJ and increased in KC. The gene discussed is PDGFD; the disease is keratoconus.