TBK1 and neoplasm: Furthermore, TT carriers for TBK1 rs7486100 A/T, regulatory of tumor-associated macrophages, associated with worse PFS (HR = 1.94, 95% CI: 1.04–3.61, p-val = 0.037) and OS (HR = 1.86, 95% CI: 0.94–3.68, p-val = 0.074) in KRAS wt patients from APD, partially in line with results in26, where any T was associated with worse PFS in KRAS wt mCRC patients.