A total of 12 DEGs, includingHAND2-AS1, PEG3, OGN, SFRP4, TFAP2A, MMP12, TOP2A, ASPM, CFB, WT1, FOXL2, and EFEMP1, were identified as candidate genes for endometrial cancer. The gene discussed is EFEMP1; the disease is endometrial cancer.