In support of this, rh proSP-C BRICHOS prevents fibril formation of medin, a fragment of lactadherin that forms amyloid in the human aortic wall25, and we have recently found that Bri2 BRICHOS potently inhibits amyloid formation and toxicity of type 2 diabetes associated islet amyloid polypeptide (IAPP)26. This evidence concerns the gene IAPP and type 2 diabetes mellitus.