PTEN and neoplasm: Preclinical studies using combinations of those agents have already shown promising results.42–44 Moreover, the associations we found between expression of PTEN and hormonal receptors suggest that molecular stratification based on expression of PTEN and hormonal receptors may be informative for tumours that are more likely to respond to hormonal therapies (high expression of PTEN and hormonal receptors) and those that could be preferentially treated with PI3Kbeta inhibitors (low expression of PTEN and hormonal receptors).