PTEN and neoplasm: Recent in silico and IHC analysis of human prostate tumours showed that PTEN loss in primary prostate tumours was also associated with lower CD8+ TIL counts and an immunosuppressive tumour environment mediated by infiltrating FoxP3+ T cells.41 However, in the same study, PTEN-deficient metastasis to the lymph nodes showed increased counts of CD8+ T cells.