Interestingly, these opposite associations are also demonstrated in our study, since PTEN loss was associated with low counts of CD8+ T cells in HGSOC cases and high counts in CCOC cases, supporting the hypothesis that not only PI3K activation may influence recruitment of cytotoxic T cells but also that these processes may be distinctly regulated in different subtypes of ovarian cancer. This evidence concerns the gene PIK3CA and ovarian carcinoma.